Carbamoyloxyamino-1,4-benzodiazepines and medicaments containing these compounds
AssigneeHoechst Aktiengesellschaft
InventorsManfred Forsch, Hermann Gerhards
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Abstract
What are disclosed are 1,4-benzodiazepines, having a carbamoyloxyamino group, of the following formula I ##STR1## tautomers thereof of the following formula IA ##STR2## physiologically tolerated salts thereof, said compounds having an anxiolytic action without sedating, a process for the preparation of these new compounds, pharmaceutical agents which contain the active compounds, and methods for treating anxiety states with said compounds.
Claims9
A carbamoyloxyamino-1,4-benzodiazepine of the formula ##STR12## or of the formula ##STR13## or a physiologically tolerated salt of such a compound, wherein R.sup.1 is halogen, nitro, or trifluoromethyl;
- R.sup.2 is phenyl, pyridyl, or phenyl which is mono- or di-substituted by C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, hydroxy, halogen, or trifluoromethyl;
- R.sup.3 is hydrogen, C.sub.1 -C.sub.4 alkyl, monoalkylcarbamoyloxy, or dialkylcarbamoyloxy;
- and
- R.sup.4 is phenyl or phenyl which is mono- or di-substituted by halogen, nitro, cyano, trifluoromethyl, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, hydroxy, or dialkylamino having 1-4 carbon atoms in each alkyl.
7-Chloro-2-(3-chlorophenylcarbamoyloxyamino)-5-phenyl-3H-1,4-benzodiazep ine.
5 -(2-Chlorophenyl)-2-(3-chlorophenylcarbamoyloxyamino)-7-nitro-3H-1,4-benzod iazepine.
7-Chlo ro-5-(2-chlorophenyl)-2-(3-chlorophenylcarbamoyloxyamino)-3H-1,4-benzodiaze pine.
2- (3-Chlorophenylcarbamoyloxyamino)-5-(2-fluorophenyl)-7-nitro-3H-1,4-benzodi azepine.
2-(3- Chlorophenylcarbamoyloxyamino)-7-nitro-5-phenyl-3H-1,4-benzodiazepine.
7-Chloro-2-(3-chlorophenylcarbamoyloxyamino)-5-(2-fluorophenyl)-3H- 1,4-benzodiazepine.
Dependencies are inferred from the claim text.