Parasiticidal pour-on compositions
AssigneeJanssen Pharmaceutica NV
InventorsJohn M. Ballany, Andrew R. Galbraith
Life of this patent
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Abstract
The present invention relates to novel stable pour-on compositions for eradicating or controlling parasites in non-human animals, said compositions containing tetramisole and/or levamisole and an organophosphate along with an acid to improve the efficiency of the composition.
Claims19
A pour-on or spot-on composition for eradicating or controlling parasites in non-human animals, said compositions comprising
- (a) from 1 to 30% by weight of tetramisole and/or levamisole;
- (b) from 2 to 15% by weight of phosmet;
- and
- (c) one or more optionally substituted aliphatic carboxylic acids, having each a pK.sub.a -value comprised between 0.6 and 6 in a molar excess of 1.5:1 to 12:1 over tetramisole and/or levamisole
- in a suitable solvent and/or carrier.
A pour-on or spot-on composition for eradicating or controlling parasites in non-human animals, said composition comprising
- (a) from 3 to 7% by weight of levamisole;
- (b) from 5 to 12% by weight of phosmet;
- (c) from 1 to 10% by weight of acetic acid;
- and
- (d) from 5 to 15% by weight of citric acid
- in a suitable solvent and/or carrier.
A pour-on or spot-on composition for eradicating or controlling parasites in non-human animals, said composition comprising
- (a) from 10 to 30% by weight of tetramisole and/or levamisole;
- (b) from 2 to 15% by weight of phosmet;
- and
- (c) one or more optionally substituted aliphatic carboxylic acids, having each a pK.sub.a -value comprised between 0.6 and 6 in a molar excess of 1.5:1 to 12:1 over tetramisole and/or levamisole.
- in a medium comprising at least 50% by weight of a solvent and/or carrier consisting of one or more alcohols, having the formula
- HO--(CH.sub.2 --CH.sub.2 --O).sub.m --R (III)
- wherein m is the integer 1, 2 or 3;
- and R is lower alkyl.
A pour-on or spot-on composition for eradicating or controlling parasites in non-human animals, said composition comprising
- (a) from 10 to 30% by weight of tetramisole and/or levamisole;
- (b) from 2 to 15% by weight of phosmet;
- and
- (c) one or more optionally substituted aliphatic carboxylic acids, having each a pK.sub.a -value comprised between 0.6 and 6 in a molar excess of 1.5:1 to 12:1 over tetramisole and/or levamisole
- in a medium comprising at least 50% by weight of a solvent and/or carrier consisting of one or more alcohols having the formula
- HO--(CH.sub.2 --CH.sub.2 --O).sub.2 --R (III-a)
- wherein R is lower alkyl.
A pour-on or spot-on composition for eradicating or controlling parasites in non-human animals, said composition comprising
- (a) from 10 to 30% by weight of tetramisole and/or levamisole;
- (b) from 2 to 15% by weight of phosmet;
- and
- (c) one or more optionally substituted aliphatic carboxylic acids, having each a pK.sub.a -value comprised between 0.6 and 6 in a molar excess of 1.5:1 to 12:1 over tetramisole and/or levamisole.
- in a medium comprising at least 50% by weight of 2-(2-butoxyethoxy)-ethanol.
A pour-on or spot-on composition for eradicating or controlling parasites in non-human animals, said composition comprising
- (a) from 3 to 7% by weight of levamisole;
- (b) from 5 to 12% by weight of phosmet;
- (c) from 1 to 10% by weight of acetic acid;
- and
- (d) from 5 to 15% by weight of citric acid
- in a medium comprising at least 50% by weight of 2-(2-butoxyethoxy)ethanol.
Dependencies are inferred from the claim text.