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US 4,395,406 AGranted
5-Halopyrimid-2-ones
AssigneeNyegaard & Co. A/S
InventorsMikkel J. Gacek, Reidar Oftebro, Soren Laland, Kjell Undheim
Life of this patent
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Abstract
Novel derivatives of pyrimid-2-one having interesting pharmacological properties are described. The compounds of the invention have been found to be of use in the control of, and in particular in the inhibition of the metaphase of malignant tumours and leukaemias. Processes for the preparation of the novel compounds and pharmaceutical compositions containing them are also described.
Claims9
A compound of the formula:
- ##STR16## wherein X represents a fluorine, chlorine or bromine atom;
- R.sup.1 and R.sup.2, which may be the same or different, each represent hydrogen or a group Alk or SAlk;
- and R.sup.3 represents a group Alk;
- Alk being an alkyl, alkenyl or alkynyl group having up to 4 carbon atoms, which group may carry one or more halogen atoms or oxo groups or optionally substituted hydroxy, mercapto, carboxyl, carboxamido or amino groups, wherein the optional substituent is a C.sub.1-4 alkyl, alkenyl, or alkynyl group, with the proviso that R.sup.3 is other than a methyl or ethyl group;
- or salts thereof.
2 more elements
Dependencies are inferred from the claim text.