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US 4,395,404 AGranted
Synthetic thymosin .beta..sub.3 and .beta..sub.4 analogues
AssigneeThe George Washington University
InventorsTeresa L. K. Low, Allan L. Goldstein
Life of this patent
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Abstract
Novel peptides representing fragments of thymosin .beta..sub.3 and .beta..sub.4 have been synthesized and are active agents affecting regulation, differentiation and function of thymus dependent lymphocytes and macrophages.
Claims13
A peptide of the formula
- R-Gly-Glu-Ser-R.sub.1
- wherein R represents H-Q, Q-Ala-, Q-Gln-Ala, Q-Glu-Lys-Gln-Ala, Q-Gln-Glu-Lys-Gln-Ala-, Q-Glu-Gln-Glu-Lys-Gly-Ala, Q-Ile-Glu-Gln-Glu-Lys-Gin-Ala, Q-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-, Q-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gin-Ala, or Q-Gln-Sar-wherein Q represents H or acyl;
- and R.sub.1 represents -OH, -A-C or -A-B-C wherein A represents Asp or Asn, B represents -Glu-Ile-Thr- and C represents -Ala-Lys-Thr-Oh.
- and the pharmaceutically acceptable acid or base addition salts thereof.
1 more element
Dependencies are inferred from the claim text.