Back to results
US 4,395,401 AGranted
Renally active dipeptides
AssigneeSmithKline Beckman Corporation
InventorFrancis R. Pfeiffer
Life of this patent
Estimating the term…
Abstract
A group of prolyl-.alpha.-lower alkylphenylalanine dipeptides have been found to improve kidney function especially on cumulative administration. A species is N-4-(4'-hydroxyphenyl)-butyryl-L-propyl-D,L-.alpha.-methyl-3,4-dimethoxyph enylalanyl-L-arginine.
Claims11
A chemical compound of the structural formula:
- ##STR6## in which:
- R is ##STR7## or --NH--(CH.sub.2).sub.3 --NH.sub.2 ;
- R.sup.1, R.sup.2 or R.sup.3 are each hydrogen, hydroxy or methoxy;
- and
- R.sup.4 is lower alkyl of 1-3 carbons;
- or pharmaceutically acceptable acid addition salts thereof.
3 more elements
A chemical compound of the structural formula:
- ##STR8## in which:
- R.sup.1, R.sup.2 and R.sup.3 are each hydrogen, hydroxy or methoxy;
- and
- R.sup.4 is lower alkyl of 1-3 carbons.
1 more element
Dependencies are inferred from the claim text.