Use of lipid amines formulated with fat or lipid emulsions as vaccine adjuvants
AssigneePfizer Inc.
InventorsJohn S. Wolff, III, George R. Hemsworth, Keith E. Jensen
Life of this patent
Estimating the term…
Abstract
N,N-higher alkyl-N',N'-bis(2-hydroxyethyl)-propanediamines and N,N-higher alkyl-xylylenediamines formulated with fat or lipid emulsions are useful as vaccine adjuvants of low toxicity. These compositions are useful in conjunction with known immunological substances in order to induce or enhance the immunogenic response. Preferred compositions employ N,N-higher alkyl-N',N'-bis(2-hydroxyethyl)propanediamines, particularly N,N-dioctadecyl-N',N'-bis(2-hydroxyethyl)-propanediamine in Intralipid.
Claims12
A method of inducing or enhancing the immunogenic response of an antigen in man or an animal which comprises parenteral co-administration to said man or animal of said antigen and a pharmaceutical composition which comprises a compound of the formula ##STR2## or a pharmaceutically acceptable acid addition salt thereof wherein R.sub.1 and R.sub.2 are each alkyl of 12 to 20 carbon atoms;
- and a lipid or fat emulsion comprising about 10% vegetable oil and about 1.2% phospholipids;
- in an amount to effectively induce or enhance the immunogenic response of said antigen.
Dependencies are inferred from the claim text.