Process for the preparation of a furan derivative
AssigneeGlaxo Group Limited
InventorJohn W. Clitherow
Life of this patent
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Abstract
Ranitidine is prepared by reacting cystamine of formula (II) ##STR1## either with a nitroethenamine of formula (III) ##STR2## where L is a leaving group such as alkylthio, e.g. methylthio, or with a compound of formula (IV) ##STR3## where L is a leaving group as defined above, followed by reaction with methylamine, to give a disulphide of formula (V) ##STR4## which is then reacted with 5-[(dimethylamino)methyl]-2-furanmethanol under acid conditions.
Claims9
A process for the preparation of ranitidine of formula (I) ##STR10## which comprises reacting cystamine of formula (II) ##STR11## either with a nitroethenamine of formula (III) ##STR12## where L is a leaving group, or with a compound of formula (IV) ##STR13## where L is a leaving group, followed by reaction with methylamine, to give a disulphide of formula (V) ##STR14## which is then reacted with 5-[(dimethylamino)methyl]-2-furanmethanol under acid conditions.
Dependencies are inferred from the claim text.