Chemical compounds

A compound of the formula ##STR60## wherein p is 1 or 2;

• R.sup.1 is hydroxy or NR.sup.2 R.sup.3 ;
• R.sup.2 and R.sup.3 each are independently hydrogen, (lower)alkyl, (lower)alkenyl, (lower)alkynyl, cyclo(lower)alkyl(lower)alkyl, hydroxy(lower)alkyl, (lower)alkoxy(lower)alkyl, (lower)alkylthio(lower)alkyl, 2-fluoroethyl, 2,2,2-trifluoroethyl or cyano(lower)alkyl, or, when R.sup.2 is hydrogen, R.sup.3 may also be cyclo(lower)alkyl, amino(lower)alkyl, (lower)alkylamino(lower)alkyl, di(lower)alkylamino(lower)alkyl, pyrrolidino(lower)alkyl, piperidino(lower)alkyl, piperazino(lower)alkyl, substituted pyridyl(lower)alkyl wherein the pyridyl ring may contain one substituent selected from (lower)alkyl, (lower)alkoxy, hydroxy, amino and halogen, amino, (lower)alkylamino, di(lower)alkylamino, hydroxy, (lower)alkoxy, 2,3-dihydroxypropyl, cyano, amidino, (lower)alkylamidino, A'--(CH.sub.2).sub.m' Z'(CH.sub.2).sub.n' --, phenyl, phenyl(lower)alkyl, substituted phenyl or substituted phenyl(lower)alkyl, wherein the phenyl ring may contain one or two substituents independently selected from (lower)alkyl, hydroxy, (lower)alkoxy and halogen or one substituent selected from methylenedioxy, trifluoromethyl and di(lower)alkylamino;
• or R.sup.2 and R.sup.3, taken together, may be --CH.sub.2 CH.sub.2 X(CH.sub.2).sub.r --;
• r is an integer of from 1 to 3, inclusive;
• X is methylene, sulfur, oxygen or N-R.sup.4, provided that, when r is 1, X is methylene;
• R.sup.4 is hydrogen, (lower)alkyl, (lower)alkenyl, (lower)alkynyl, (lower)alkanoyl or benzoyl;
• m and m' each are independently an integer of from zero to 2, inclusive;
• n and n' each are independently an integer of from 2 to 4, inclusive;
• Z and Z' each are independently sulfur, oxygen or methylene;
• A and A' each are independently phenyl, imidazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, triazolyl, thiadiazolyl, oxadiazolyl, furyl, thienyl or pyridyl;
• provided that A and A' independently may contain one or two substituents, the first substituent being selected from (lower)alkyl, hydroxy, trifluoromethyl, halogen, amino, hydroxymethyl, (lower)alkoxy, ##STR61## and --(CH.sub.2).sub.q NR.sup.5 R.sup.6, and the second substituent being selected from (lower)alkyl, hydroxy, trifluoromethyl, halogen, amino, hydroxymethyl and (lower)alkoxy;
• q is an integer of from 0 to 6, inclusive;
• R.sup.14 and R.sup.15 independently are hydrogen or (lower)alkyl, or, if R.sup.14 is hydrogen, R.sup.15 also may be (lower)alkanoyl or benzoyl, or R.sup.14 and R.sup.15, taken together, may be ethylene;
• and
• R.sup.5 and R.sup.6 each are independently hydrogen, (lower)alkyl, (lower)alkenyl, (lower)alkynyl, (lower)alkoxy(lower)alkyl, cyclo(lower)alkyl or phenyl, provided that R.sup.5 and R.sup.6 may not both be cyclo(lower)alkyl or phenyl;
• or R.sup.5 and R.sup.6, taken together with the nitrogen atom to which they are attached, may be pyrrolidino, methylpyrrolidino, dimethylpyrrolidino, piperidino, methylpiperidino, dimethylpiperidino, hydroxypiperidino, homopiperidino, heptamethyleneimino or octamethyleneimino;
• or a nontoxic, pharmaceutically acceptable salt, hydrate, solvate or N-oxide thereof.