Back to results
US 4,394,507 AGranted
Process for production of encainide
AssigneeMead Johnson & Company
InventorGary D. Madding
Life of this patent
Estimating the term…
Abstract
An improved process for the preparation of 4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide has been developed. The process comprises essentially three steps starting with methyl anthranilate and 2-picoline and features a novel low-pressure hydrogenation sequence.
Claims2
A process for preparing 4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide (I), which comprises:
- ##STR4## (a) reacting methyl N-p-anisoylanthranilate (III) ##STR5## with 2-picolyllithium to give 2-(2-pyridylacetyl)-p-anisanilide (II);
- ##STR6## (b) hydrogenating an acid addition salt of II in glacial acetic acid in the presence of a platinum catalyst until hydrogen uptake reaches 3 equivalents;
- (c) replacing the platinum catalyst with palladium-on-carbon catalyst and continuing hydrogenation until 2 more equivalents of hydrogen are absorbed;
- and
- (d) adding excess 37% formalin and continuing hydrogenation until hydrogen absorption ceases.
2 more elements
Dependencies are inferred from the claim text.