Immunotherapeutic agent for tumors comprising lipopolysaccharide as an active component
OwnerChisato Maruyamainventor
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Abstract
Disclosed is a novel immunotherapeutic agent for tumors, which comprises as an active component a lipopolysaccharide derived from human tubercle bacillus or a lipopolysaccharide formed by chemically modifying said lipopolysaccharide.
Claims5
An immunotherapeutic agent for tumors, which comprises as an effective component lipopolysaccharide comprising, arabinomannan as a polysaccharide and fatty acids bonded to said arabinomannan through an ester linkage, the fatty acid content in said lipopolysaccharide being 3 to 28%, said lipopolysaccharide being obtained by hot water extraction and purification of the cell body of human tubercle bacillus, Mycobacterium tuberculosis strain Aoyama B or Mycobacterium tuberculosis strain H.sub.37 R.sub.v.
An immunotherapeutic agent for tumors, which comprises as an effective component lipopolysaccharide prepared by bonding a fatty acid to arabinomannan through an ester linkage, said arabinomannan being obtained by alkali extraction and purification of the cell body of human tubercle bacillus, Mycobacterium tuberculosis strain Aoyama B or Mycobacterium tuberculosis strain H.sub.37 R.sub.v, the fatty acid content in said lipopolysaccharide being 3 to 28%.
An immunotherapeutic agent for tumors, which comprises as an effective component lipopolysaccharide prepared by bonding a fatty acid to lipoarabinomannan through an ester linkage, said lipoarabinomannan being obtained by hot water extraction and purification of the cell body of human tubercle bacillus, Mycobacterium tuberculosis strain Aoyama B or Mycobacterium tuberculosis strain H.sub.37 R.sub.v, the fatty acid content in said lipopolysaccharide being 3 to 28%.
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