Adsorbent for the affinity-specific separation of macromolecular materials
AssigneeBoehringer Mannheim GmbH
InventorsWerner Muller, Hans Bunemann
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Abstract
Adsorbents are provided for the affinity-specific separation of macromolecular materials, particularly biopolymers, the adsorbents comprising a polymeric carrier on to which an affine residue for the macromolecular material is covalently bound, either directly or via polymeric spacer. Preferred affine residue is comprised of a specific complex formers which are base-specific and/or structure specific for the macromolecular material. The invention also provides novel complex formers comprising a certain dyestuff residues and processes for their preparation.
Claims7
Process for the preparation of an adsorbent for the affinity-specific separation of nucleic acids, comprising a polymeric carrier material onto which an affine residue group consisting of a base and/or structure specific complex former for nucleic acids, is covalently bound wherein said polymeric carrier material is first formed from at least one monomer which additionally possesses a functional group via which the affine residue for the biopolymer can be bound directly or via a polymeric spacer, the polymeric carrier material is optionally comminuted to the desired particle size and then the affine residue for the biopolymer is grafted on either directly or by copolymerization in the presence of at least one further monomer as co-monomer so that particles of the desired size are produced.
Dependencies are inferred from the claim text.