Radioimmunoassay reagents
OwnerJan I. Thorellinventor
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Abstract
Attenuator compositions useful as reagents in an improved internal sample attenuator counting method for radioimmunoassays are described. These compositions comprise an attenuator material that have a high capacity to absorb emitted radiation from a radioligand of the radioimmunoassay and are combined with an immunologically reactive material which interacts with components of the radioimmunoassay or combined with an absorbent of the free radiolabelled component to separate bound from free radioligand.
Claims11
A composition for separating free and bound radioligands within a radioimmunoassay, said bound radioligand being formed as a reaction product from reagents of the radioimmunoassay;
- the composition comprising individual particles capable of sedimenting in said assay and containing:
- (1) as a first active component, an attenuator having a high capacity to absorb emitted radiation of the radioligand and being selected from the group consisting of silver, cadmium, tungsten, bismuth and oxides thereof, and
- (2) as a second active component a material capable of binding said free radioligand or reaction product and being selected from the group consisting of charcoal, antibodies, antigens and biologically non-immune active binders.
A composition comprising individual particles each containing bismuth oxide as a first active component dispersed within a polyacrylamide support matrix, and a non-immune type binder as a second active component covalently coupled to the surface of said support matrix.
Dependencies are inferred from the claim text.