Hydroxybenzohydroxamic acids, benzamides and esters as ribonucleotide reductase inhibitors
OwnerBartholomeus van't Riet, Howard L. Elford +1inventors
InventorsBartholomeus van't Riet, Howard L. Elford, Galen L. Wampler
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Abstract
Di and trihydroxybenzohydroxamic acids, amides, alkyl substituted amides and phenyl esters, ribonucleotide reductase inhibitors.
Claims10
A method of inhibiting ribonucleotide reductase which comprises administering to a mammal carrying a tumor having a relatively high ribonucleotide reductase level, an amount of a compound according to the following formula effective to inhibit ribonucleotide reductase ##STR3## wherein Z and Z' are individually H or OH, at least one of Z and Z' being OH, and R.sup.1 is NHOH or O-phenyl.
A compound of the formula ##STR4## wherein n is 2 or 3.
A compound of the formula ##STR5## wherein Z is H or OH.
Dependencies are inferred from the claim text.