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US 4,394,385 AGranted
Treatment of gray matter edema
AssigneeMerck & Co., Inc.
InventorEdward J. Cragoe, Jr.
Life of this patent
Estimating the term…
Abstract
The invention relates to the treatment of gray matter edema in the brain or spinal chord by the administration of benzofuranyloxyacetic acids, indeno[5,4-b]furancarboxylic acids, their analogs and salts thereof.
Claims17
A method of treating persons with gray matter edema which comprises administering to such a person an effective amount of a compound of the formulae:
- ##STR2## wherein R.sup.1 is H, CH.sub.3 or Cl
- R.sup.2 is CH.sub.3 or Cl
- R.sup.3 is alkyl or alkenyl of one through six carbons;
- cycloalkyl or cycloalkylalkyl of four through seven carbons;
- phenyl, unsubstituted or substituted with chloro or methyl;
- benzyl;
- or thienyl
- R.sup.4 is H, alkyl of one through five carbons, or R.sup.4 and R.sup.3 taken together with the carbon to which they are attached may be joined to form a cycloalkyl radical of five or six carbons, and
- R.sup.5 is (1) furyl, (2) thienyl, (3) phenyl, unsubstituted or substituted with methyl, methoxy or halo, or (4) benzyl, unsubstituted or substituted with methyl or halo
- or the pharmaceutically acceptable salt, ester, or amide derivative thereof.
7 more elements
Dependencies are inferred from the claim text.