Co-ordination compound of platinum
AssigneeJohnson Matthey Public Limited Company
InventorsPaul C. Hydes, Derek R. Hepburn
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Abstract
The compound ##STR1## useful for the chemotherapeutic treatment of cancer or malignant neoplasms is provided in substantially pure form by a method of preparation involving a novel intermediate adduct with dimethylacetamide.
Claims3
A process for the preparation of a co-ordination compound of platinum in substantially pure form and having the structure ##STR6## comprising reacting cis-dichloro-di(isopropylamine)platinum(II) with hydrogen peroxide, isolating the product, dissolving the said product in N,N-dimethylacetamide, isolating the resulting product which comprises a 1:1 adduct of the said compound with N,N-dimethylacetamide and thereafter removing the said N,N-dimethylacetamide under vacuum at a temperature less than 80.degree. C.
A composition of matter comprising a 1:1 adduct of cis-dichloro-trans-dihydroxy-bis(isopropylamine)platinum(IV) with dimethylacetamide.
Dependencies are inferred from the claim text.