US 4,393,863 A · Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders

Abstract

A novel system and method for treating ischemic neurologic tissue is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the cerebospinal pathway. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability of the nutrient emulsion. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxic-ischemic and other diseased neurologic tissue during treatment are provided.

Claims18

Dependent claims

A method of treating hypoxic-ischemic neurologic tissue, in mammals, comprising:

(a) providing a physiologically acceptable synthetic oxygenatable fluid;
(b) oxygenating said oxygenatable fluid to produce an oxygenated fluid;
(c) injecting a substantially continuous stream of said oxygenated fluid into the cerebrospinal fluid pathway, at a first injection point;
(d) substantially continuously withdrawing fluid from said cerebrospinal fluid pathway at a second point which is selected to create a circulation of said oxygenated fluid in the vicinity of said ischemic tissue;
whereby ischemic neurologic tissue will be oxygenated and otherwise nourished by said fluid.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

06/275,116Filed 18 Jun 1981 · division

Priority

14 Aug 1980

Granted

19 Jul 1983

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

A61K 9/0026
Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in…
A61K 9/0029
Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in…
A61K 31/02
Medicinal preparations containing organic active ingredients: halogenated hydrocarbons
A61M 3/02
Medical syringes, e.g. enemata; Irrigators: enemata; Irrigators

Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders

Life of this patent

Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders

Life of this patent

Abstract

Claims18