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US 4,393,242 AGranted
Process for preparing methylvanillyl ketone from isoeugenol
AssigneeMerck & Co., Inc.
InventorMeyer Sletzinger
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Abstract
Methylvanillyl ketone is prepared from a "through process" involving oxidation of isoeugenol followed by subsequent acidic hydrolysis.
Claims6
A through process for preparing methylvanillyl ketone which comprises:
- (1) direct oxidation of an unprotected isoeugenol in an aqueous solution of an organic acid to obtain a reaction mixture containing unprotected isoeugenol glycol as an intermediate therein;
- said organic acid being selected from the group consisting of formic acid, acetic acid, propionic acid, trichloroacetic acid, or trifluoroacetic acid;
- (2) heating said reaction mixture at a temperature of about 25.degree.-100.degree. C. with an aqueous solution of a strong acid in an inert solvent;
- said strong acid being selected from the group consisting of sulfuric acid, alkyl or aryl sulfonic acid, hydrobromic acid, hydrochloric acid, or phosphoric acid;
- and,
- (3) recovering methylvanillyl ketone directly from said acid-treated reaction mixture without isolating said unprotected isoeugenol glycol intermediate.
3 more elements
Dependencies are inferred from the claim text.