Optically active phosphines
OwnerJohn K. Stilleinventor
Life of this patent
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Abstract
The compounds (R)-1,2-bis(diphenylphosphino)-3-benzyloxypropane and (R)-1-tert-butoxy-2,3-bis(diphenylphosphino)propane are precursors to new rhodium-based asymmetric reaction catalysts having the formula: ##STR1## wherein R is benzyl or tert-butyl.
Claims6
(R)-1,2-bis(diphenylphosphino)-3-benzyloxypropane.
A process for producing (R)-1,2-bis(diphenylphosphino)-3-benzyloxypropane, comprising chemically reacting 1,2-O-ditosyl-3-O-benzyl-D-glycerol with sodium diphenylphosphine.
(R)-1-tert-butoxy-2,3-bis(diphenylphosphino)propane.
A process for producing (R)-1-tert-butoxy-2,3-bis(diphenylphosphino)propane, comprising chemically reacting (+)-1-tert-butyl-2,3-paratoluenesulfonyl glycerol with sodium diphenylphosphine to form an intermediate product, contacting said intermediate product sequentially with nickel(II) chloride and an alkali metal thiocyanate to form the complex [Ni(SCN)(bisphosphine)SCN], and contacting and reacting said complex with an alkali metal cyanide.
(R)-1,2-bis(diphenylphosphino)propane-3-ol.
A process for producing (R)-1,2-bis(diphenylphosphino)propane-3-ol, comprising chemically reacting (R)-1-tert-butoxy-2,3-bis(diphenylphosphino)propane with anhydrous trifluoroacetic acid to effect acid-catalyzed cleavage of the tert-butyl group.
Dependencies are inferred from the claim text.