Production of nonhygroscopic salts of 4-hydroxybutyric acid
OwnerJoseph Klosainventor
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Abstract
A method for the production of nonhygroscopic magnesium and/or calcium salts of 4-hydroxybutyric acid. A member of the group consisting of magnesium hydroxide, magnesium oxide, magnesium carbonate, calcium hydroxide, calcium oxide and calcium carbonate is reacted with 4-hydroxybutyric acid and/or 4-butyrolactone in an aqueous solution. The solution is crystallized at a sufficiently low temperature for producing a solid nonhygroscopic salt. Waterfree calcium-4-hydroxybutyrate and waterfree as well as hydrated magnesium-4-hydroxybutyrate are added to pharmaceutically acceptable carrier or filler material for production of tranquilizing and/or sleeping drugs.
Claims21
Waterfree calcium-4-hydroxybutyrate of the formula Ca(COOCH.sub.2 CH.sub.2 CH.sub.2 OH).sub.2.
Magnesium-4-hydroxybutyrate of the formula Mg(COOCH.sub.2 CH.sub.2 CH.sub.2 OH).sub.2.
A method for the production of magnesium and/or calcium salts of 4-hydroxybutyric acid comprising
- reacting a member of the group consisting of 4-hydroxybutyric acid, 4-butyrolactone and mixtures thereof with a member of the group consisting of magnesium hydroxide, magnesium oxide, magnesium carbonate, calcium hydroxide, calcium oxide, calcium carbonate and mixtures thereof in an aqueous solution;
- and
- crystallizing the resulting solution at initial temperatures of from about 40.degree. to 80.degree. C. sufficiently low to produce a solid nonhygroscopic salt.
A pharmaceutical composition providing narcotic effects comprising
- a nonhygroscopic salt of 4-hydroxybutyric acid;
- and
- a pharmaceutically acceptable carrier and/or filler material.
A method for the production of magnesium and/or calcium salts of 4-hydroxybutyric acid comprising reacting a member of the group consisting of 4-hydroxybutyric acid, 4 butyrolactone and mixtures thereof with a member of the group consisting of magnesium hydroxide, magnesium oxide, magnesium carbonate, calcium hydroxide, calcium oxide, calcium carbonate and mixtures thereof in an aqueous solution;
- and crystallizing the resulting material in the presence of a non-solvent at a temperature sufficiently low to produce a solid nonhygroscopic salt.
Dependencies are inferred from the claim text.