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US 4,393,235 AGranted
Process for producing p-hydroxyphenyl/acetic acid
AssigneeImperial Chemical Industries PLC
InventorsAlan Mitchell, Thomas Bailey
Life of this patent
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Abstract
A process for the preparation of p-hydroxyphenylacetic acid by reducing p-hydroxymandelic acid with a stannous salt. The product is a valuable intermediate for the preparation of the .beta.-adrenergic blocking agent atenolol.
Claims5
A process for the manufacture of p-hydroxyphenylacetic acid which comprises reducing p-hydroxymandelic acid with a stannous salt under acidic conditions, the reduction being carried out in aqueous solution in the presence of a mineral acid at a temperature of up to 100.degree. C.
Dependencies are inferred from the claim text.