Compounds and methods for changing calcium metabolism within the cells of a mammal
AssigneeThe Ohio State University Research Foundation
InventorsDonald T. Witiak, Ralf G. Rahwan
Life of this patent
Estimating the term…
Abstract
2-alkyl-5,6-dialkoxy (or 5,6 alkylenedioxy) indenes and indane-1-di- or trialkylammonium salts are useful as calcium antagonists, for example in arrhythmia. The compounds are prepared from the known corresponding 2,5,6-substituted indene-1-dimethylammonium salts by alkylation and/or hydrogenation.
Claims30
A 2-alkyl-5,6-dialkoxyindene-1-trialkylammonium salt of Formula II ##STR1## wherein the two R.sub.1 's together form an alkylene group of 1 to 3 carbon atoms, R.sub.2 is an alkyl group of 1 to about 8 carbon atoms, a cycloalkyl group of 3 to about 7 carbon atoms or a phenyl group, each R.sub.3 independently is an alkyl group of 1 to 3 carbon atoms and X.sup.- is an anion.
A cis 2-alkyl-5,6-dialkoxy-1-dimethylaminoindane of Formula IIIA ##STR2## wherein the two R.sub.1 groups together form an alkylene group of 1 to 3 carbon atoms, R.sub.2 is an alkyl group of 1 to about 8 carbon atoms, a cycloalkyl group of 3 to about 7 carbon atoms or a phenyl group, and each R.sub.3 independently is an alkyl group of 1 to 3 carbon atoms.
A cis 2-alkyl-5,6-dialkoxyindane-1-trialkylammonium salt of Formula IVA ##STR3## wherein the two R.sub.1 groups together form an alkylene group of 1 to 3 carbon atoms, R.sub.2 is an alkyl group of 1 to about 8 carbon atoms, a cycloalkyl group of 3 to about 7 carbon atoms or a phenyl group, each R.sub.3 independently is an alkyl group of 1 to 3 carbon atoms and X.sup.- is an anion.
Dependencies are inferred from the claim text.