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US 4,393,077 AGranted
1-Methylene-1-phenylguanidine compounds
AssigneeWilliam H. Rorer, Inc.
InventorsGeorge H. Douglas, Henry F. Campbell
Life of this patent
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Abstract
Compounds having the formula: ##STR1## wherein X.sub.1, X.sub.2, R, R.sub.1, R.sub.2 and R.sub.3 are as set forth hereinafter, their preparation and uses as ganglionic blocking agents are disclosed.
Claims4
A method for ganglionic blocking which comprises administering an effective amount of a compound of the formula ##STR4## and the pharmaceutically acceptable salts thereof, wherein X.sub.1 and X.sub.2 each represent a member selected from the group consisting of hydrogen, halo, trifluoromethyl, acyl, alkyl, hydroxy, alkoxy and amino,
- R.sub.1, R.sub.2, and R.sub.3 each represent a member selected from the group consisting of hydrogen, lower alkyl and lower alkenyl and
- R represents a member selected from the group consisting of cycloalkyl, cycloalkenyl and aryl,
- also, R.sub.3 and either R.sub.1 or R.sub.2 can constitute a methylene bridge, --(CH.sub.2).sub.2 -- or --(CH.sub.2).sub.3 --, resulting in the formation of a five- or six-membered ring.
Dependencies are inferred from the claim text.