Anti-inflammatory and analgesic gel composition
AssigneeHisamitsu Pharmaceutical Co., Inc.
InventorsKanji Noda, Akira Nakagawa, Tetsuya Yamagata, Hiroyuki Ide
Life of this patent
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Abstract
An anti-inflammatory analgesic gel composition comprising (1) ketoprofen and/or flurbiprofen as the effective ingredient, as well as (2) a glycol, lower alcohol, water and/or a mixture of a lower alcohol with water, (3) a gel-forming agent and, if desired, (4) a solubilizing agent and/or non-ionic surface-active agent as the ingredients of a gel base for the gel composition.
Claims15
An anti-inflammatory and analgesic gel composition comprising, by weight, 0.5-10% of ketoprofen as the effective ingredient, 2-40% of a glycol selected from the group consisting of propylene glycol, butylene glycol, polyethylene glycol, polypropylene glycol, polyethylene glycol dodecyl ether and glycerine, 20-55% of water, up to 60% of a lower alcohol selected from the group consisting of ethanol, denatured ethanol, propanol and isopropanol, 0.5-5% of a gelling agent selected from the group consisting of carboxyvinyl polymers, hydroxycellulose, methylcellulose, carboxymethylcellulose, hydroxypropylcellulose and alginic acid-propylene glycol ester and 0.1-3% of a neutralizing agent selected from the group consisting of triethanolamine, diethylamine, triethylamine, diisopropylamine and diisopropanolamine.
A method of improving the anti-inflammatory analgesic effects of an inflammatory analgesic gel compositions which comprises topically applying said composition to the skin of animals and human beings, the gel composition comprising, by weight, 0.5-10% of ketoprofen as the effective ingredient, 2-40% of a glycol selected from the group consisting of propylene glycol, butylene glycol, polyethylene glycol, polypropylene glycol, polyethylene glycol dodecyl ether and glycerine, 20-55% of water, up to 60% of a lower alcohol selected from the group consisting of ethanol, denatured ethanol, propanol and isopropanol, 0.5-5% of a gelling agent selected from the group consisting of carboxyvinyl polymers, hydroxyethylcellulose, methylcellulose, carboxymethylcellulose, hydroxypropylcellulose and alginic acid-propylene glycol ester and 0.1-3% of a neutralizing agent selected from the group consisting of triethanolamine, diethylamine, triethylamine, diisopropylamine and diisopropanolamine.
An anti-inflammatory and analgesic gel composition comprising by weight, 3-7% of ketoprofen as the effective ingredient 2-40% of a glycol selected from the group consisting of propylene glycol, butylene glycol, polyethylene glycol, polypropylene glycol, polyethylene glycol dodecyl ether and glycerine, 20-55% of water, up to 60% of a lower alcohol selected from the group consisting of ethanol, denatured ethanol, propanol and isopropanol, 0.5-5% of a gelling agent selected from the group consisting of carboxyvinyl polymers, hydroxyethylcellulose, methylcellulose, carboxymethylcellulose, hydroxypropylcellulose and alginic acid-propylene glycol ester and 0.1-3% of a neutralizing agent selected from the group consisting of triethanolamine, diethylamine, triethylamine, diisopropylamine and diisopropanolamine.
Dependencies are inferred from the claim text.