8-Arylalkyl-3-phenyl-3-nortropanols and salts thereof
AssigneeC. H. Boehringer Sohn
InventorsAdolf Langbein, Herbert Merz, Rainer Sobotta, Rudolf Bauer, Hans M. Jennewein, Joachim Mierau
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Abstract
Compounds of the formula ##STR1## wherein Ar is ##STR2## R.sub.1 is hydrogen, fluorine, bromine, methyl or methoxy; X is .dbd.CO, .dbd.CH--CN, .dbd.CH--OH, --O--, --S--, --NH--, ##STR3## and R is hydrogen, 4-fluoro, 4-chloro, 4-trifluoromethyl, 3-trifluoromethyl, 3-trifluoromethyl-4-chloro, 4-methyl or 4-methoxy; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as neuroleptics.
Claims6
A compound of the formula ##STR166## wherein Ar is ##STR167## R.sub.1 is hydrogen, fluorine, bromine, methyl or methoxy;
- X is .dbd.CO, .dbd.CH--CN, .dbd.CH--OH, --O--, --S--, --NH--, ##STR168## and R is hydrogen, 4-fluoro, 4-chloro, 4-trifluoromethyl, 3-trifluoromethyl, 3-trifluoromethyl-4-chloro, 4-methyl or 4-methoxy;
- or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.