US 4,393,060 A · Isocyanuric acid derivatives, method of preparation, therapeutic compositions with a cytostatic action and therapeutic method

Abstract

N-substituted-diglycidyl-isocyanurates having the formula: ##STR1## wherein R represents a hydrocarbon-containing radical selected from the group consisting of alkyl, aryl, aralkyl, alkaryl and cycloalkyl, optionally containing: (a) heterocycles except epoxides, and unsaturation, and (b) substituents selected from the group consisting of halogen, hydroxyl, amino, N-substituted amino, mercapto, alkylmercapto, arylmercapto, alkylsulfoxy, arylsulfoxy, alkoxy, aryloxy and acyloxy, and R.sub.1 represents a member selected from the group consisting of hydrogen and alkyl having from 1 to 4 carbon atoms, as well as the method for preparing said N-substituted-diglycidyl-isocyanurates, therapeutic compositions with cytostatic action comprising said N-substituted-diglycidyl-isocyanurates, and a method of treatment of malignant neoplasias in warm-blooded animals by administering a therapeutically effective amount of said N-substituted-diglycidyl-isocyanurate.

Claims10

Dependent claims

A cytostatic composition consisting essentially of a cytostatically effective amount of at least one N-substituted-diglycidyl-isocyanurate having the formula:

##STR14## wherein R has from 1 to 15 carbon atoms, which R is a hydrocarbon-containing radical selected from the group consisting of alkyl, aryl, aralkyl, alkaryl, cycloalkyl, and unsaturated derivatives thereof, which R may be further substituted by:
heterocycles selected from the group consisting of piperidine, hexamethylenimine, morpholine, benzthiazol-2-ylthio and benzimidazol-2-ylthio, and further substituents on said R selected from the group consisting of halogen, hydroxyl, amino, N-substituted amino having the formula:
--NHR.sub.2 and --NR.sub.2 R.sub.3
wherein R.sub.2 and R.sub.3 together have a total of no more than 8 carbon atoms and are members selected from the group consisting of alkyl and alkyl substituted by hydroxy, halogen and alkoxy, mercapto, alkylmercapto, alkylmercapto substituted by hydroxy, halogen and alkoxy, arylmercapto, alkylsulfoxyl, arylsulfoxyl, alkoxy, aryloxy and alkanoyloxy and aroyloxy, and R.sub.1 represents a member selected from the group consisting of hydrogen and alkyl having from 1 to 4 carbon atoms, and a pharmaceutically acceptable carrier therefor.

1 more element

Dependencies are inferred from the claim text.

Isocyanuric acid derivatives, method of preparation, therapeutic compositions with a cytostatic action and therapeutic method

Life of this patent

Isocyanuric acid derivatives, method of preparation, therapeutic compositions with a cytostatic action and therapeutic method

Life of this patent

Abstract

Claims10