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US 4,393,054 AGranted
Method of treating cardiac arrhythmia
AssigneeThe Upjohn Company
InventorHarry R. Allen
Life of this patent
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Abstract
The 3-(5'-adenylate) of lincomycin- and clindamycin-type compounds in which the propyl hygric acid moiety has been replaced by different cyclic amino acids can be used to treat cardiac arrhythmia in humans and animals.
Claims3
The method for the treatment of cardiac arrhythmia in a patient which comprises administering a pharmaceutical carrier and a cardiac arrhythmia inhibiting quantity of a compound of the formula
- wherein R is ##STR3## R.sub.1 is H, C.sub.1 -C.sub.8 -alkyl;
- R.sub.11 is OH, OCH.sub.3, halogen (Cl, Br, I), --SCH.sub.2 CH.sub.2 OH, --SCH.sub.2 CH.sub.2 CH.sub.2 OH, SCH.sub.3 ;
- R.sub.12 is CH.sub.3, CH.sub.2 CH.sub.3, --CH.sub.2 CH.sub.2 OH, ##STR4## or the pharmaceutically acceptable acid addition salts thereof.
Dependencies are inferred from the claim text.