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US 4,393,053 AGranted
Thiolic derivatives or erythromycin having therapeutic activity and pharmaceutical compositions containing them
AssigneeRefarmed S.A.
InventorJacques Gonella
Life of this patent
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Abstract
The thiolic salts of erythromycin and of the propionic ester of erythromycin with thenoyl alpha-mercaptopropionylglycine find therapeutical use in the cases in which erythromycin or its propionic ester are used and are generally endowed with very low toxicity and high hematic levels.
Claims7
Thiolic derivatives of erythromycin and of the propionic ester of erythromycin having the formula
- R--X (1)
- wherein R is the radical of thenoyl alpha-mercaptopropionylglycine ##STR3## and X is the radical of erythromycin or of 3'-propionic ester of erythromycin having the formula ##STR4## in which R.sub.1 is H or CH.sub.3 --CH.sub.2 --CO.
Dependencies are inferred from the claim text.