Combination of thiopeptin and other related sulfur-containing cyclic polypeptide antibiotics with rumen-active diimides to improve ruminant feed efficiency
AssigneeMerck & Co., Inc.
InventorsFrancis P. Baylis, Gary E. Smith
Life of this patent
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Abstract
Combinations of thiopeptin or one of its analogs with a pyromellitic diimide are shown to synergistically increase the feed efficiency of economically important ruminant animals, especially cattle, sheep, and goats.
Claims4
An orally administered synergistic combination useful for increasing the feed efficiency of ruminants which comprises a finished feed product and a synergistic combination of from 0.0001% to 0.01% by weight of thiopeptin with from 0.0001% to 0.02% by weight of a pyromellitic diimide compound selected from the group consisting of
- (a) pyromellitic diimide;
- (b) (N-(2-hydroxyethyl)pyromellitic diimide;
- and
- (c) N,N'-bis-(2-hydroxyethyl)pyromellitic diimide.
A method for synergistically increasing the feed efficiency of ruminant animals which comprises orally administering to the ruminant animal, its feed containing an effective amount of a synergistic combination of from 0.0001 to 0.01% by weight of thiopeptin and from 0.0001 to 0.02% by weight of a pyromellitic diimide compound selected from the group consisting of
- (a) pyromellitic diimide;
- (b) N-(2-hydroxyethyl)pyromellitic diimide;
- and
- (c) N,N'-bis-(2-hydroxyethyl)pyromellitic diimide.
Dependencies are inferred from the claim text.