.beta.-Lactamase inhibitors
AssigneeHoffmann-La Roche Inc.
InventorsDennis D. Keith, John P. Tengi, Manfred Weigele
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Abstract
A .beta.-lactamase inhibitor of the formula ##STR1## and the pharmaceutically acceptable salts thereof are presented. Also presented are intermediates and synthetic processes for the manufacture of the formula I compound. The compound inhibits the activity of enzymes which inactivate certain .beta.lactam antibiotics.
Claims6
A compound of the formula ##STR5## and the pharmaceutically acceptable salts thereof.
A compound of the formula ##STR6## wherein R.sub.2 is a conventional carboxy protecting group.
A compound of the formula ##STR7## wherein R.sub.2 is hydrogen or a conventional carboxy protecting group.
A compund of the formula ##STR8## wherein R.sub.2 is hydrogen or a converted carboxy protecting group.
A compound of the formula ##STR9## wherein R.sub.1 is chloro, bromo or iodo and R.sub.2 is hydrogen or a conventional carboxy protecting group.
A compound of the formula ##STR10## wherein R.sub.1 is chloro, bromo or iodo.
Dependencies are inferred from the claim text.