Process for the preparation of (2-amino-thiazol-4yl)-acetic acid hydrochloride
AssigneeLonza Ltd.
InventorsAlfred Huwiler, Leander Tenud
Life of this patent
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Abstract
Process for the simplified preparation of (2-aminothiazol-4-yl)-acetic acid hydrochloride in light-stable form, in high purity and in good yields, by the reaction of thiourea with 4-chloroacetoacetyl chloride.
Claims10
Process for the preparation of (2-aminothiazol-4-yl)-acetic acid hydrochloride comprising suspending thiourea in water, adding 4-chloroacetoacetyl chloride, which is dissolved in a chlorohydrocarbon, to the suspension at a temperature of 5.degree. to 10.degree. C., and then completing the reaction at a temperature of 25.degree. to 30.degree. C., said (2-aminothiazol-4-yl)-acetic acid hydrochloride being in light-stable form, having a high degree of purity, and being stable both in solution and as a solid.
Process for the preparation of (2-aminothiazol-4-yl)-acetic acid hydrochloride consisting of suspending thiourea in water, adding 4-chloroacetoacetyl chloride, which is dissolved in a chlorohydrocarbon, to the suspension at a temperature of 5.degree. to 10.degree. C., and then completing the reaction at a temperature of 25.degree. to 30.degree. C., said (2-aminothiazol-4-yl)-acetic acid hydrochloride being in light-stable form, having a high degree of purity, and being stable both in solution and as a solid.
Dependencies are inferred from the claim text.