Phenyl-quinolizidines
AssigneeHoffmann-La Roche Inc.
InventorsRene Imhof, Emilio Kyburz
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Abstract
Phenyl-quinolizidines of the general formula ##STR1## wherein X is hydrogen, fluorine, chlorine, lower-alkoxy, lower-alkyl or trifluoromethyl; Y is hydrogen, fluorine, chlorine, lower-alkoxy or lower-alkyl; and R.sup.1 is acyl, acylamino or a group A of the formula ##STR2## wherein R.sup.2 is oxygen or sulfur; R.sup.3 is hydrogen or lower-alkyl; and one of R.sup.4 and R.sup.5 is hydrogen and the other is bromine, iodine, cyano, lower-alkoxycarbonyl or sulfamoyl, as racemates or enatiomers, as well as acid addition salts thereof, utilizing various intermediates, are described. The foregoing compounds are useful as neuroleptic, antiemetic and analgesic agents.
Claims5
A compound of the formula ##STR31## wherein X is hydrogen, fluorine, chlorine, lower-alkoxy, lower-alkyl or trifluoromethyl;
- Y is hydrogen, fluorine, chlorine, lower-alkoxy, or lower-alkyl;
- R.sup.2 is oxygen or sulfur;
- R.sup.3 is hydrogen or lower-alkyl;
- and one of R.sup.4 and R.sup.5 is hydrogen and the other is bromine, iodine, cyano, lower-alkoxycarbonyl or sulfamoyl
- in the form of its racemate or its enantiomers, as well as a pharmaceutically acceptable acid addition salt thereof.
A compound of the formula ##STR32## wherein X is hydrogen, fluorine, chlorine, lower-alkoxy, lower-alkyl or trifluoromethyl;
- Y is hydrogen, fluorine, chlorine, lower-alkoxy or lower-alkyl;
- and one of R.sup.4 and R.sup.5 is hydrogen and the other is bromine, iodine, cyano, lower-alkoxycarbonyl or sulfamoyl,
- in the form of its racemate or its enantiomers, as well as a pharmaceutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.