Phenethanolamines, compositions containing the same, and method for effecting weight control
AssigneeEli Lilly and Company
InventorsJack Mills, Klaus K. Schmiegel, Walter N. Shaw
Life of this patent
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Abstract
Optically active N-3-(4-substituted phenyl)propyl-.beta.-phenethanolamines are provided as well as pharmaceutical compositions containing such compounds. A method for effecting weight control in obese animals utilizing optically active phenethanolamines is disclosed. Novel intermediates useful in the preparation of optically active .beta.-phenethanolamines are provided.
Claims20
A pharmaceutical formulation useful in the control of weight in obese animals comprising as active principle an amount effective for controlling weight of an optically active phenethanolamine of the formula ##STR11## wherein:
- R.sub.2 is hydrogen, methyl or ethyl;
- R.sub.3 is aminocarbonyl or methylaminocarbonyl;
- C is an asymmetric carbon atom having the R absolute stereochemical configuration;
- C is an asymmetric carbon atom when R.sub.2 is methyl or ethyl, and when asymmetric is of the S absolute stereochemical configuration;
- and the non-toxic pharmaceutically acceptable acid addition salts thereof, in combination with a suitable pharmaceutical carrier therefor.
A method for effecting weight control in an obese animal in need of treatment which comprises administering to such animal an amount effective for controlling weight of a compound of the formula ##STR12## wherein:
- R.sub.2 is hydrogen, methyl or ethyl;
- R.sub.3 is aminocarbonyl or methylaminocarbonyl;
- C is an assymetric carbon atom having the R absolute stereochemical configuration;
- C is an asymmetric carbon atom when R.sub.2 is methyl or ethyl, and when asymmetric is of the S absolute stereochemical configuration;
- and the non-toxic pharmaceutically acceptable acid addition salts thereof.
A method for improving the leanness of meat in livestock animals comprising administering an effective amount of a compound of the formula ##STR13## wherein:
- R.sub.2 is hydrogen, methyl or ethyl;
- R.sub.3 is aminocarbonyl or methylaminocarbonyl;
- C is an asymmetric carbon atom having the R absolute stereochemical configuration;
- C is an asymmetric carbon atom when R.sub.2 is methyl or ethyl, and when asymmetric is of the S absolute stereochemical configuration;
- and the non-toxic pharmaceutically acceptable acid addition salts thereof.
Dependencies are inferred from the claim text.