Cyanobenzano[b]pyrans
AssigneeBeecham Group Limited
InventorJohn M. Evans
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Abstract
2,2-Dimethyl-3,4-dihydro-2H-benzo[b]pyran-3-ols bearing an amino group in the 4-position and a cyano group in the benzo ring, their salts, esters and ethers, demonstrate excellent vasodilatory activity. The compounds, of which trans-2,2-dimethyl-4-isopropylamino-6-cyano-3,4-dihydro-2H-benzo[b]pyran-3 -ol is a representative embodiment, can be prepared from the corresponding 3,4-epoxy derivative upon treatment with an amine.
Claims14
A compound selected from the group consisting of benzo[b]pyran of the formula:
- ##STR3## and the pharmaceutically acceptable acid addition salts thereof wherein R is hydrogen, alkyl of 1 to 3 carbon atoms, alkanoyl of up to 8 carbon atoms or benzoyl,
- NR.sub.1 R.sub.2 is pyrrolidino, and the depicted cyano group is the 6-position.
The compound which is trans-2,2-dimethyl-4-pyrrolidino-6-cyano-3,4-dihydro-2H-benzo[b]pyran-3-ol or its hydrochloride salt.
A pharmaceutical composition which comprises an anti-hypertensively effective amount of trans-2,2-dimethyl-4-pyrrolidino-6-cyano-3,4-dihydro-2H-benzo[b]pyran-3-ol or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.