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US 4,391,814 AGranted
Derivatives of antiphlogistically effective carboxylic acids, their preparation and medicinal use
AssigneeSchering Corporation
InventorHelmut Vorbruggen
Life of this patent
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Abstract
Compounds of Formula I ##STR1## wherein R.sub.1 is the residue of an antiphlogistically effective carboxylic acid of the formula R.sub.1 COOH, n is an integer 1, 2, or 3, and X is oxygen, sulfur, or optionally alkylated nitrogen have valuable antiinflammatory activity.
Claims8
A compound of the formula ##STR19## wherein n is 1;
- X is oxygen;
- and
- R.sub.1 is of the formula:
- ##STR20## wherein R.sub.2 is (i) alkanoyl or alkanoyloxy each of 2-6 carbon atoms;
- (ii) phenoxy, anilino or 1-naphthylamino;
- or (iii) phenoxy, anilino or 1-naphthylamino, each of which is mono- or di-substituted by halogen, trifluoromethyl, or alkyl of 1-4 carbon atoms;
- U is --CH.dbd. and
- V is a carbon-to-carbon bond or methylene;
- or ##STR21## wherein R.sub.11 is alkyl of up to 6 carbon atoms, phenyl or phenyl mono- or di-substituted by chlorine or fluorine;
- one of R.sub.12, R.sub.13, and R.sub.14 is methylenyl;
- one or two of R.sub.12, R.sub.13, and R.sub.14 is phenyl or phenyl mono- or di-substituted by chlorine or fluorine;
- or one of R.sub.12, R.sub.13, and R.sub.14 is hydrogen.
9 more elements
2-[1-(6-Methoxy-2-naphthyl)ethyl]-2-oxazoline.
Dependencies are inferred from the claim text.