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US 4,391,812 AGranted
2-(Substitutedpiperidylmethyl) propane nitriles and compositions thereof
AssigneeMerck & Co., Inc.
InventorsRichard A. Dybas, Nathaniel Grier, Bruce E. Witzel
Life of this patent
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Abstract
Antimicrobial agents suitable for use in aqueous systems for their preservation against biodeterioration include substitutedpiperidinomethylpropenenitriles and propanenitriles. The unsaturated compounds are prepared by reaction of a suitable piperidine with cyano acetic acid and formaldehyde: the propane derivatives therefrom by nucleophilic addition.
Claims5
A compound of the formula:
- ##STR11## where Z is ##STR12## R" is hydrogen, C.sub.1 -C.sub.18 alkyl, benzyl, or phenethyl;
- R is in the 2-, 3-, or 4-positions and is hydroxy or hydroxyalkyl;
- R' is amino, loweralkylamino, or diloweralkylamino;
- n is an integer from 1 to 4;
- m is the integer 0 or at least 1;
- and X is a suitably charged anion.
3 more elements
2-Cyano-1-dimethylamino-3-(4-hydroxypiperidino)propane.
Dependencies are inferred from the claim text.