5(1-Piperazinyl(imidazo[2,1-b][1,3,5]benzothiadiazepines

A 5-diazacycloalkyl-imidazo[2,1-b][1,3,5]benzothidiazepine compound of the formula ##STR8## wherein one of R.sub.1 and R.sub.2 is hydrogen, lower alkyl or alkanoyl, halogeno, cyano, carboxy, lower carbalkoxy, carboamoyl, sulfamoyl, mono- or di-lower alkyl-(carbamoyl or sulfamoyl), and the other of R.sub.1 and R.sub.2 is hydrogen, lower alkyl or halogeno;

• Ph is 1,2-phenylene, unsubstituted or substituted by on member selected from lower alkyl, lower alkoxy, lower alkylthio, halogeno, trifluoromethyl, sulfamoyl, mono- or di-lower alkyl-sulfamoyl, each of C.sub.m H.sub.2m and C.sub.n H.sub.2n is lower alkylene separating both nitrogen atoms by 2 carbon atoms;
• and R.sub.3 is hydrogen, lower alkyl, lower alkanoyl, lower alkoxycarbonyl, or lower hydroxyalkyl wherein the hydroxy group is separated from the nitrogen atom by at least 2 carbon atoms;
• the S-oxides;
• the N-oxides;
• or a pharmaceutically acceptable salt thereof.