Substituted tetrahydropyridazino-(1,6-A)benzimidazoles and use as bronchodilators
AssigneeThe Dow Chemical Company
InventorsCatherine A. Alexander, Robert J. Cregge, Norton P. Peet
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Abstract
Substituted tetrahydropyridazino[1,6-a]benzimidazole compounds such as 2-methylamino-6,7,8,9-tetrahydropyridazino[1,6-a]benzimidazole are prepared by reacting a 2-halo-6,7,8,9-tetrahydropyridazino[1,6-a]benzimidazole with an appropriate amine. The compounds are useful as bronchodilators.
Claims5
A compound of the formula:
- wherein --NRR' is (lower alkyl)amino, di(lower alkyl)amino, 1-pyrrolidinyl, 1-piperidinyl, methyl-1-piperidinyl, hexahydroazepin-1-yl, 4-methyl-1-piperazinyl, 4-methylhexahydro-1,4-diazepin-1-yl and 4-morpholinyl;
- and the pharmaceutically acceptable acid addition salts of
A method of producing bronchodilation which comprises administering to a mammal in need thereof an effective amount of a compound of the formula ##STR4## wherein --NRR' is (lower alkyl)amino, di(lower alkyl)amino, 1-pyrrolidinyl, 1-piperidinyl, methyl-1-piperidinyl, hexahydroazepin-1-yl, 4-methyl-1-piperazinyl, 4-methylhexahydro-1,4-diazepin-1-yl and 4-morpholinyl;
- and the pharmaceutically acceptable acid addition salts of said compound.
Dependencies are inferred from the claim text.