IUD Arrangement
OwnerSeth T. Shaw, Jr.inventor
Life of this patent
Estimating the term…
Abstract
A medicated intrauterine device insertable in and retained in the uterus for a predetermined time period and having a drug with a controlled release rate and said drug comprising a guanidine such as an aromatic monoguanidine, an aromatic diguanidine, a non-aromatic monoguanidine or a non-aromatic diguanidine to provide anti-fibrinolytic, anti-proteolytic and/or anti-conceptive action. The drug is one or a mixture of more than one of such guanidines, or a mixture of one or more of such guanidines with one or more amidines.
Claims17
A medicated intrauterine device of the type insertable into the uterus for retention therein for a predetermined time period and comprising, in combination, a uterus insertable body member comprising a polymer matrix having an external surface contacting the uterus, a coating on a first portion of said external surface of said body member comprising a drug, and said drug compromising at least a guanidine in one of a non-biodegradable monomer, non-biodegradable dimer, non-biodegradable oligomer and non-biodegradable, cross-linked polymer form and said drug chemically bonded to said surface of said polymer matrix.
A medicated intrauterine device of the type insertable in the uterus for retention therein for a predetermined time period and comprising, in combination;
- a uterus insertable body member having an external surface contacting the uterus, and said body member comprising a polymer matrix and at least one drug with said polymer matrix and said at least one drug providing an anti-fibrinolytic effect, a reversible anti-fertility effect, and an anti-proteolytic effect, and said at least one drug comprising at least a guanidine, and said at least one drug and said polymer matrix selected to provide said at least one drug releasable at a predetermined rate from said body member to the uterus;
- a coating on a first portion of said external surface of said body member comprising one of a biodegradable cross-linked polymer and biodegradable cross-linked copolymer form of a second drug, and said second drug comprising at least a guanidine, and said second drug covalently bonded to said surface of said polymer matrix;
- said second drug selected from the class consisting of:
- (a) a mixture of an amidine and a guanidine;
- (b) a mixture of more than one amidine and a guanidine;
- (c) a mixture of an amidine and more than one guanidine;
- (d) a mixture of more than one amidine and more than one guanidine;
- (e) a guanidine;
- and
- (f) a mixture of more than one guanidine;
- and
- said one drug selected from the class consisting of:
- (a) a mixture of an amidine and a guanidine;
- (b) a mixture of more than one amidine and a guanidine;
- (c) a mixture of an amidine and more than one guanidine;
- (d) a mixture of more than one amidine and more than one guanidine;
- (e) a guanidine;
- and
- (f) a mixture of more than one guanidine.
A medicated intrauterine device of the type insertable in the uterus for retention therein for a predetermined time period and comprising, in combination:
- a uterus insertable body member having an external surface contacting the uterus, and said body member comprising a polymer matrix and at least one drug with said polymer matrix and said at least one drug providing an anti-fibrinolytic effect, a reversible anti-fertility effect, and an anti-proteolytic effect, and said at least one drug comprising at least a guanidine, and said at least one drug and said polymer matrix selected to provide said at least one drug releasable at a predetermined rate from said body member to the uterus;
- and
- wherein said at least one drug comprises a soft hydrogel coating on a first portion of said external surface of said body member, and said at least one drug is in the form of one of a biodegradable cross-linked polymer and biodegradable copolymer covalently bonded to said body member.
Dependencies are inferred from the claim text.