Method for producing zinc etheromycin from fermentation broths
AssigneeInternational Minerals & Chemical Corp.
InventorJerome L. Martin
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Abstract
Zinc complexes of glycolic monovalent monoglycoside polyether antibiotics are provided for use as coccidiostats and growth-promoting agents when administered to poultry and for use as active agents for improving cardiovascular function in animals. Zinc complexes of the type disclosed can be prepared by adding soluble zinc salt to a fermentation beer containing the glycolic monovalent monoglycoside polyether antibiotic to thereby form an insoluble, recoverable biomass containing the desired zinc antibiotic complex.
Claims18
A method for producing a zinc complex of etheromycin said method comprising:
- (a) fermenting a fermentation broth inoculated with a Streptomyces hygroscopicus microorganism capable of producing etheromycin by fermentation of the broth for a period of time and under suitable fermentation conditions in order to produce said antibiotic in said fermentation broth;
- and
- (b) providing in said etheromycin containing fermentation broth a water-soluble zinc salt in an amount sufficient to form a zinc complex of etheromycin, which complex is insoluble in the fermentation broth.
A method for producing a zinc complex of etheromycin which comprises complexing etheromycin zinc or zinc precursor under zinc-etheromycin complexing conditions to produce a zinc complex of etheromycin, the zinc-etheromycin complexing conditions including a fermentation broth in which etheromycin is produced.
Dependencies are inferred from the claim text.