US 4,201,770 A · Antigenic modification of polypeptides

Abstract

Modified hormones or fragments of hormones are useful in producing antibodies when administered to an animal. Said antibodies in turn cause neutralization of endogenous natural protein hormones. The modification may be accomplished by attaching various kinds of modifying groups to the hormone or fragment. Modification may, for example, be achieved by chemically coupling diazosulfanilic acid groups to the hormone or fragment. The protein hormones to which this procedure can be applied are mammalian protein reproductive hormones such as, for example, Follicle Stimulating Hormone (FSH), or Human Chorionic Gonadotropin (HGG). These modified hormone or fragment may be administered to animals for the purpose of contraception, abortion, or treatment of hormone related disease states and disorders.

Claims24

Dependent claims

A method for controlling fertility in primate animals having naturally occurring endogenous Chroionic Gonadotropin hormone by neutralizing the biological action of the endogenous hormone, comprising the steps of:

administering to said primate animal an immunologically effective amount of the hormone, a subunit thereof, a peptide fragment of the subunit or a synthetically derived peptide having a sequence analogous to at least a portion of said subunit;
said hormone, subunit, fragment or synthetically derived peptide being modified by the coupling thereof with a non-endogenous material to effect the formation, following said administration, of antibodies having a specificity to endogenous Chorionic Gonadotropin;
thereby inhibiting the fertility of said primate animal by preventing one or more normal biological functions of the endogenous Chorionic Gonadotropin hormone.

Dependencies are inferred from the claim text.

Antigenic modification of polypeptides

Life of this patent

Antigenic modification of polypeptides

Life of this patent

Abstract

Claims24