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AssigneeMay & Baker Limited
InventorsBarbara Joyce Broughton, Bryan John Large, Stuart Malcolm Marshall, David Lord Pain, Kenneth Robert Harry Wooldridge
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8-Azapurin-6-ones substituted in the 2-position by an unsubstituted or substituted phenyl or naphthyl group, or by an alkenyl or alkynyl group, a cycloalkyl group, an alkyl group contaning 2 to 10 carbon atoms, or an alkyl group containing 1 to 10 carbon atoms carrying one or more substitutents selected from halogen atoms and hydroxy, cycloalkyl, alkoxy, phenyl and substituted phenyl groups, and pharmaceutically acceptable salts thereof, possess pharmacological properties useful, for example, in the treatment of allergic bronchial asthma.
A pharmaceutical composition useful for the treatment of allergic respiratory disorders manifested by the interaction of tissue-fixed antibodies with specific antigens in human subjects which comprises at least one 8-azapurin-6-one derivative of the formula:
The composition of claim 1 in liquid form capable of producing an aerosol for administration to human subjects suffering from a respiratory disorder comprising, in a pressurized pack, a solution or suspension of an effective amount of at least one 8-azapurin-6-one as defined in claim 15, or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable liquid medium and a volatile liquid propellant in amount sufficient to produce an aerosol.
Dependencies are inferred from the claim text.