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US 3,953,502 AGranted
Cyclopentane derivatives
AssigneeImperial Chemical Industries PLC
InventorsJean Bowler, Edward Douglas Brown, Peter Robert Marsham, Edward Raymond Halstead Walker
Life of this patent
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Abstract
The disclosure relates to novel pentanor prostaglandin analogues, for example 15-(5-chloroindan-2-yl)-9.alpha.,11.alpha.,15-trihydroxy-16,17,18,19,20-pe ntanor-5-cis, 13-trans-prostadienoic acid and 15-(5-chloroindan-2-yl)-11.alpha.,15-dihydroxy-9-oxo-16,17,18,19,20-pentan or-5-cis,13-trans-prostadienoic acid and the 1-ester and 1-alcohol derivatives thereof, to a process for their manufacture, to compositions containing them, and to their use in a method of inducing luteolysis.
Claims6
A cyclopentane derivative of the formula:
- ##SPC15##
- wherein R.sup.1 is carboxy or alkoxycarbonyl of up to 11 carbon atoms,
- R.sup.2 is hydroxy or alkanoyloxy of 1 to 4 carbon atoms, and
- R.sup.3 is hydrogen, or
- R.sup.2 and R.sup.3 together are oxo,
- X is ethylene or cis-vinylene,
- Y is ethylene or trans-vinylene,
- Z is a direct bond or alkylidene of 1 to 5 carbon atoms,
- either A and B are each is alkylidene of 1 to 5 carbon atoms or
- A is ethylene, and
- B is a direct bond,
- R.sup.4 is hydrogen or alkyl of 1 to 4 carbon atoms, or
- Cr.sup.4 together with an adjacent carbon of A or B forms a double bond,
- R.sup.5 is halogen or alkyl, alkoxy or halogenoalkyl each of 1 to 5 carbon atoms,
- which compound bears 0 or 1 alkyl substituent of 1 to 4 carbon atoms on the trimethylene group, and for those compounds wherein R.sup.1 is carboxy, the pharmaceutically or veterinarily acceptable base addition salts thereof.
12 more elements
Dependencies are inferred from the claim text.