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US 3,933,822 AGranted
Azapurinones
AssigneeMay & Baker Limited
InventorsBarbara Joyce Broughton, Bryan John Large, Stuart Malcolm Marshall, David Lord Pain, Kenneth Robert Harry Wooldridge
Life of this patent
Estimating the term…
Abstract
8-Azapurin-6-ones substituted in the 2-position by a phenyl group carrying in a meta-position a sulphamoyl substituent, and also a hydroxy, alkoxy or alkylthio substituent para with respect to the said sulphamoyl grouping, and pharmaceutically acceptable salts thereof, possess pharmacological properties useful in the treatment of allergic respiratory disorders, for example allergic bronchial asthma.
Claims13
An 8-azapurin-6-one derivative of the formula:
- ##SPC7## 40/14
- wherein R.sup.1 represents hydroxy, or alkoxy or alkylthio each containing 1 to 10 carbon atoms, R.sup.2 represents hydrogen, alkyl of 1 to 10 carbon atoms, alkyl of 1 to 10 carbon atoms carrying one or more substituents selected from the group consisting of hydroxy and phenyl, cycloalkyl containing 3 to 8 carbon atoms, phenyl, or phenyl carrying one or more substituents selected from the group consisting of alkyl or alkoxy each containing 1 to 6 carbon atoms, halogen, nitro and trifluoromethyl, R.sup.3 represents hydrogen, alkyl of 1 to 10 carbon atoms, or alkyl of 1 to 10 carbon atoms carrying one or more substituents selected from the group consisting of hydroxy and phenyl, or cycloalkyl containing 3 to 8 carbon atoms, and R.sup.4 represents hydrogen, methyl or ethyl, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.