Chimeric compounds useful in treating diseases

A compound of Formula (I):

• or a pharmaceutically acceptable salt, stereoisomer, solvate, or tautomer thereof, wherein
• Ring A is
• Ring B and Ring C are each independently selected from C3-C10 cycloalkyl, aryl, 3- to 10-membered heterocyclyl, and heteroaryl;
• L1, L2, and L4 are independently selected from bond, C1-C6 alkylenyl, C2-C6 alkenylenyl, C2-C6 alkynylenyl, C(O)—, C(O)NRL—, —C(O)O, —NRL—, —NRLC(O)—, —NRLC(O)NRL—, —NRLC(O)O—, —O—, —OC(O)—, OC(O)NRL—, —OC(O)O—, and —S(O)o—, wherein the alkylenyl, alkenylenyl, and alkynylenyl is optionally substituted with one or more substituents independently selected from halogen, —OH, —CN, —NO2, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C10 cycloalkyl, aryl, 3- to 10-membered heterocyclyl, and heteroaryl;
• L3 is selected from C1-C6 alkylenyl, C2-C6 alkenylenyl, and C2-C6 alkynylenyl, wherein the alkylenyl, alkenylenyl, and alkynylenyl is optionally substituted with one or more halogen, —OH, —CN, —NO2, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C10 cycloalkyl, aryl, 3- to 10-membered heterocyclyl, and heteroaryl;
• provided that when s is 0 then L1 and L2 form a single bond;
• each RL is independently selected from hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C10 cycloalkyl, aryl, 3- to 10-membered heterocyclyl, and heteroaryl;
• X1 is selected from NR2, CR2, and C(R2)2;
• X6 is selected from NR3, CR3, and C(R3)2;
• R1 and R4 are each independently selected from halogen, OH, CN, —NO2, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C10 cycloalkyl, aryl, 3- to 10-membered heterocyclyl, and heteroaryl, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, aryl, heterocyclyl, or heteroaryl is optionally substituted with one or more substituents independently selected from halogen, —OH, —CN, —NO2, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C10 cycloalkyl, aryl, 3- to 10-membered heterocyclyl, and heteroaryl;
• R2 and R3 are each independently selected from hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C10 cycloalkyl, aryl, 3- to 10-membered heterocyclyl, and heteroaryl, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, aryl, heterocyclyl, or heteroaryl is optionally substituted with one or more substituents independently selected from halogen, —OH, —CN, —NO2, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C10 cycloalkyl, aryl, 3- to 10-membered heterocyclyl, and heteroaryl;
• or R2 and R3, together with the atoms to which they are attached, may come together to form 4- to 10-membered heterocyclyl, aryl, or heteroaryl, optionally substituted with one or more substituents independently selected from halogen, OH, —CN, —NO2, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C10 cycloalkyl, aryl, 3- to 10-membered heterocyclyl, and heteroaryl;
• or R2 may come together with any part of L2 to form 3- to 10-membered heterocyclyl or heteroaryl, optionally substituted with one or more substituents independently selected from halogen, —OH, —CN, —NO2, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C10 cycloalkyl, aryl, 3- to 10-membered heterocyclyl, and heteroaryl;
• or R2 may come together with any part of L3 to form 3- to 10-membered heterocyclyl or heteroaryl, optionally substituted with one or more substituents independently selected from halogen, —OH, —CN, —NO2, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C10 cycloalkyl, aryl, 3- to 10-membered heterocyclyl, and heteroaryl;
• or R3 may come together with any part of L3 to form 3- to 10-membered heterocyclyl, aryl, or heteroaryl, optionally substituted with one or more substituents independently selected from halogen, —OH, —CN, —NO2, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C10 cycloalkyl, aryl, 3- to 10-membered heterocyclyl, and heteroaryl;
• R5 is independently selected from hydrogen, halogen, —OH, —CN, —NO2, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C10 cycloalkyl, aryl, 3- to 10-membered heterocyclyl, and heteroaryl, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, aryl, heterocyclyl, or heteroaryl is optionally substituted with one or more substituents independently selected from halogen, —OH, —CN, —NO2, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C10 cycloalkyl, aryl, 3- to 10-membered heterocyclyl, and heteroaryl;
• each R6, R7, and R10 is independently selected from hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C10 cycloalkyl, aryl, 3- to 10-membered heterocyclyl, and heteroaryl, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, aryl, heterocyclyl, or heteroaryl is optionally substituted with one or more R11;
• R8 is selected from hydrogen, halogen, —OH, —CN, —NO2, —C(O)Rx, —C(O)N(Rx)2, —C(O)ORx, —N(Rx)2, —ORx, —S(O)oRx, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C10 cycloalkyl, aryl, 3- to 10-membered heterocyclyl, and heteroaryl, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, aryl, heterocyclyl, or heteroaryl is optionally substituted with one or more substituents independently selected from halogen, —OH, —CN, —NO2, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C10 cycloalkyl, aryl, 3- to 10-membered heterocyclyl, and heteroaryl;
• each R11 is independently selected from hydrogen, halogen, —OH, —CN, —NO2, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C10 cycloalkyl, aryl, 3- to 10-membered heterocyclyl, and heteroaryl, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, aryl, heterocyclyl, or heteroaryl is optionally substituted with one or more substituents independently selected from halogen, —OH, —CN, —NO2, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C10 cycloalkyl, aryl, 3- to 10-membered heterocyclyl, and heteroaryl;
• each RX is independently selected from hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C10 cycloalkyl, aryl, 3- to 10-membered heterocyclyl, and heteroaryl, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, aryl, heterocyclyl, or heteroaryl is optionally substituted with one or more substituents independently selected from halogen, —OH, —CN, —NO2, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C10 cycloalkyl, aryl, 3- to 10-membered heterocyclyl, and heteroaryl;
• m is an integer selected from 0, 1, 2, 3, 4, 5, and 6;
• n is an integer selected from 0, 1, 2, 3, 4, 5, and 6;
• o is an integer selected from 0, 1, and 2;
• s is an integer selected from 0 and 1;
• t is an integer selected from 0 and 1;
• wherein
• aryl is cyclic, aromatic hydrocarbon groups that have 1 to 3 aromatic rings where the aromatic rings may be joined at a single point, or fused;
• heterocyclyl is saturated or partially unsaturated 3-10 membered monocyclic, 7-12 membered bicyclic (fused, bridged, or spiro rings), or 11-14 membered tricyclic ring system (fused, bridged, or spiro rings) having one or more heteroatoms selected from O, N, S, P, Se, or B;
• heteroaryl is monovalent monocyclic or polycyclic aromatic radical of 5 to 24 ring atoms, containing one or more ring heteroatoms selected from N, O, S, P, Se, or B, the remaining ring atoms being C.