Compositions and methods for treatment of septic shock
AssigneePeroxitech Therapeutics, Inc.
InventorThomas Han
Life of this patent
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Abstract
The present application provides for polypeptides for the treatment of septic shock and methods of use thereof.
Claims49
A method of treating septic shock in a subject in need thereof, the method comprising administering to the subject an effective amount of a pharmaceutical composition comprising a polypeptide comprising an amino acid sequence of:
- X1X2X3X4X5LX6X7X8X9HQIL (SEQ ID NO:
- 1)
- wherein:
- X1 is E or is absent;
- X2 is L or is absent;
- X3 is Q or is absent;
- X4 is A, T, or is absent;
- X5 is T, E, or is absent;
- X6 is H or Y;
- X7 is D or E;
- X8 is F or I;
- and
- X9 is R or K;
- or
- an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 10, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 24, 25, 26, 27, 28, 29, or 30;
- and a pharmaceutically acceptable carrier.
A method of treating subject with a significant drop in mean arterial pressure, the method comprising administering to the subject an effective amount of a pharmaceutical composition comprising a polypeptide comprising an amino acid sequence of:
- X1X2X3X4X5LX6X7X8X9HQIL (SEQ ID NO:
- 1)
- wherein:
- X1 is E or is absent;
- X2 is L or is absent;
- X3 is Q or is absent;
- X4 is A, T, or is absent;
- X5 is T, E, or is absent;
- X6 is H or Y;
- X7 is D or E;
- X8 is F or I;
- and
- X9 is R or K;
- or
- an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 10, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 24, 25, 26, 27, 28, 29, or 30;
- and a pharmaceutically acceptable carrier.
A method of preventing heart damage in a subject with diagnosed with septic shock, the method comprising administering to the subject an effective amount of a pharmaceutical composition comprising a polypeptide comprising an amino acid sequence of:
- X1X2X3X4X5LX6X7X8X9HQIL (SEQ ID NO:
- 1)
- wherein:
- X1 is E or is absent;
- X2 is L or is absent;
- X3 is Q or is absent;
- X4 is A, T, or is absent;
- X5 is T, E, or is absent;
- X6 is H or Y;
- X7 is D or E;
- X8 is F or I;
- and
- X9 is R or K;
- or
- an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 10, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 24, 25, 26, 27, 28, 29, or 30;
- and a pharmaceutically acceptable carrier, as compared to a subject not treated with the pharmaceutical composition.
A method of increasing survival of a subject with diagnosed with septic shock, the method comprising administering to the subject an effective amount of a pharmaceutical composition comprising a polypeptide comprising an amino acid sequence of:
- X1X2X3X4X5LX6X7X8X9HQIL (SEQ ID NO:
- 1)
- wherein:
- X1 is E or is absent;
- X2 is L or is absent;
- X3 is Q or is absent;
- X4 is A, T, or is absent;
- X5 is T, E, or is absent;
- X6 is H or Y;
- X7 is D or E;
- X8 is F or I;
- and
- X9 is R or K;
- or
- an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 10, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 24, 25, 26, 27, 28, 29, or 30;
- and a pharmaceutically acceptable carrier, as compared to a subject not treated with the pharmaceutical composition.
Dependencies are inferred from the claim text.