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US 2026/0306562 A1Published application
Enhancer of number of tcr clones
AssigneeKabushiki Kaisha Yakult Honsha
InventorsAyaka MAKI, Tomoaki NAITO, Saya TAJIMA, Tetsuji HORI, Satoshi MATSUMOTO
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Abstract
Provided is an enhancer of number of TCR clones containing live lactic acid bacteria as an active ingredient. Provided is an enhancer of number of TCR clones, containing live lactic acid bacteria as an active ingredient, wherein after vaccination with CD4 carrying TRBV19 such as vaccination with IFV or a virus carrying an epitope recognized by CD8 positive T cells, the number of TCR clones carrying TRBV19 is enhanced.
Claims10
A method of increasing a number of TCR clones in a subject, comprising:
- administering to the subject a composition comprising live lactic acid bacteria belonging to the genus Lacticaseibacillus as an active ingredient,
- wherein the subject has received or will receive vaccination with a virus carrying an epitope recognized by CD4 positive T cells carrying TRBV19 or CD8 positive T cells, and
- wherein the administration increases the number of TCR clones carrying TRBV19 in the subject.
Dependencies are inferred from the claim text.