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US 2026/0306555 A1Published application
Recombinant expression vector for secreting interleukin-12, and attenuated salmonella strain transformed therewith
AssigneeThe Industry & Academic Cooperation in Chungnam National University (IAC)
InventorsHyo Jin LEE, Heung Jin JEON, Solbi KIM, Eunji KIM, Minju HAN
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Abstract
The present disclosure relates to a recombinant expression vector for secretion of interleukin-12 and an attenuated Salmonella strain transformed therewith, and provides: a recombinant expression vector comprising a flgM gene and an interleukin-12 gene; an attenuated Salmonella strain transformed therewith; and a pharmaceutical composition for cancer treatment, comprising the attenuated Salmonella strain as an active ingredient.
Claims10
A recombinant expression vector comprising:
- a flgM gene;
- an interleukin-12 gene;
- and a flhDC gene, wherein the flgM gene, the interleukin-12 gene, and the flhDC gene are operably linked to an inducible promoter.
Dependencies are inferred from the claim text.