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US 2026/0306412 A1Published application
Triptolide formulations
AssigneeMinneamrita Therapeutics LLC
InventorMohana R. VELAGAPUDI
Life of this patent
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Abstract
A pharmaceutical composition containing triptolide or a derivative thereof, as well as methods of using the composition and methods of manufacturing the composition. The composition can be prepared using thermokinetic compounding and can provide improved properties, such as improved bioavailability. The composition can improve the therapeutic treatment of cancers such as pancreatic cancer, breast cancer, bladder cancer, kidney cancer, ovarian cancer, glioblastoma, or melanoma.
Claims17
A pharmaceutical composition consisting of:
- a) 38.8% w/w±15% hydroxypropyl methyl cellulose acetate succinate (HPMCAS);
- b) 37% w/w±15% microcrystalline cellulose;
- c) 15% w/w±15% mannitol;
- d) 7% w/w±15% crosslinked carboxymethyl cellulose sodium (croscarmellose sodium);
- e) 0.7% w/w±15% of magnesium stearate;
- f) 0.5% w/w±15% colloidal silica;
- and
- g) 0.1% w/w±15% to 5% w/w±15% triptolide;
- wherein the composition is an amorphous solid dispersion.
6 more elements
Dependencies are inferred from the claim text.