Coherence potential assay for brain state and cognitive change detection

A system configured for coherence potential assay for brain state and cognitive change detection, comprising:

• a processor;
• memory coupled with the processor;
• and
• instructions stored in the memory and executable by the processor to cause the system to:
• receive brain signal data from sensors connected to a subject;
• detect events in the brain signal data, wherein the events correspond to deflections exceeding a predetermined amplitude threshold;
• form a correlation matrix based on waveform similarity between the detected events;
• cluster the detected events into groups based on the correlation matrix;
• compute connectivity metrics for the clusters, wherein the connectivity metrics include mean inter-event intervals, maximum inter-event intervals, and spatial characteristics derived from sensor positions;
• compare the computed connectivity metrics to stored population benchmark values to determine brain states or cognitive changes;
• and
• output the brain states or cognitive changes.

A non-transitory computer-readable medium storing code for coherence potential assay for brain state and cognitive change detection, the code comprising instructions executable by a processor to:

• receive brain signal data from sensors connected to a subject;
• detect events in the brain signal data, wherein the events correspond to deflections exceeding a predetermined amplitude threshold;
• form a correlation matrix based on waveform similarity between the detected events;
• cluster the detected events into groups based on the correlation matrix;
• compute connectivity metrics for the clusters, wherein the connectivity metrics include mean inter-event intervals, maximum inter-event intervals, and spatial characteristics derived from sensor positions;
• compare the computed connectivity metrics to stored population benchmark values to determine brain states or cognitive changes;
• and
• output the brain states or cognitive changes.