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AssigneeTrimar Domestic Inc.
InventorsDouglas Fraser, Steven Squires, Krishna Kowlgi, Andrew Robinson, Brent Ferguson
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The invention encompasses rapid diagnostic testing devices for testing of a biological sample for sepsis, and for determining bacterial versus viral pathogen. The device comprises a channeled construct, at least one lateral flow unit, and a cassette housing for the detection of biomarkers indicative of sepsis. The lateral flow unit is at least partially disposed in the cassette housing. The lateral flow unit comprises: a sample receiving zone, a conjugate zone and a detection zone. The sample receiving zone is operatively coupled to the channeled construct for receiving the biological sample comprising at least one analyte (e.g., a biomarker). The conjugate zone comprising a conjugate particle to bind the analyte is disposed adjacent to the first side of the sample receiving zone. The detection zone is disposed adjacent to the second side of the sample receiving zone and comprises at least one binding agent for detecting the analyte and includes quantum dots to amplify the signal for high sensitivity.
A lateral flow immunoassay device comprising a lateral flow test strip, one or more quantum dots to which are conjugated antibodies for a specific biomarker, wherein the lateral flow strip has a sample pad and a wicking pad distal to the sample pad, a control line opposite the sample pad, wherein the device is capable of detecting the presence of an amount of the biomarker at picogram/mL and femtogram/mL concentrations in a biological sample, and wherein the biomarker is a biomarker for sepsis.
Dependencies are inferred from the claim text.